Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.127 0.214
biological_process el 1648 0.0 1.0 0.598 0.268
biological_process ka 1648 0.0 1.0 0.121 0.213
biological_process rf 1648 0.0 1.0 0.127 0.214
cellular_component ct 184 0.0 0.905 0.17 0.253
cellular_component el 184 0.001 0.925 0.307 0.239
cellular_component ka 184 0.0 0.972 0.174 0.258
cellular_component rf 184 0.0 0.919 0.171 0.254
disease ct 1456 0.0 1.0 0.042 0.135
disease el 1456 0.0 1.0 0.167 0.224
disease ka 1456 0.0 1.0 0.042 0.138
disease rf 1456 0.0 1.0 0.042 0.135
genetic_interaction_unweighted ct 1569 0.0 1.0 0.417 0.327
genetic_interaction_unweighted el 1569 0.0 0.999 0.423 0.319
genetic_interaction_unweighted ka 1569 0.0 1.0 0.839 0.361
genetic_interaction_unweighted rf 1569 0.0 1.0 0.416 0.326
genetic_interaction_weighted ct 1569 0.0 1.0 0.416 0.327
genetic_interaction_weighted el 1569 0.0 0.999 0.428 0.316
genetic_interaction_weighted ka 1569 0.0 1.0 0.836 0.367
genetic_interaction_weighted rf 1569 0.0 0.999 0.416 0.325
molecular_function ct 476 0.0 0.995 0.28 0.305
molecular_function el 476 0.0 0.998 0.404 0.285
molecular_function ka 476 0.0 1.0 0.277 0.307
molecular_function rf 476 0.0 0.995 0.28 0.305
pathway ct 555 0.001 1.0 0.274 0.342
pathway el 555 0.001 1.0 0.236 0.338
pathway ka 555 0.001 1.0 0.463 0.49
pathway rf 555 0.001 1.0 0.228 0.334
phenotype ct 1358 0.0 0.998 0.072 0.163
phenotype el 1358 0.0 0.998 0.253 0.195
phenotype ka 1358 0.0 1.0 0.07 0.169
phenotype rf 1358 0.0 0.998 0.072 0.164
protein_interaction_unweighted ct 1657 0.0 1.0 0.07 0.163
protein_interaction_unweighted el 1657 0.0 0.933 0.065 0.157
protein_interaction_unweighted ka 1657 0.0 1.0 0.304 0.455
protein_interaction_unweighted rf 1657 0.0 0.926 0.066 0.154
protein_interaction_weighted ct 1657 0.0 1.0 0.071 0.164
protein_interaction_weighted el 1657 0.0 0.945 0.438 0.261
protein_interaction_weighted ka 1657 0.0 1.0 0.302 0.456
protein_interaction_weighted rf 1657 0.0 0.931 0.069 0.159

Table 2. Backup position values for every kernel after integration

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels