Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	1648	0.0	1.0	0.127	0.214
biological_process	el	1648	0.0	1.0	0.598	0.268
biological_process	ka	1648	0.0	1.0	0.121	0.213
biological_process	rf	1648	0.0	1.0	0.127	0.214
cellular_component	ct	184	0.0	0.905	0.17	0.253
cellular_component	el	184	0.001	0.925	0.307	0.239
cellular_component	ka	184	0.0	0.972	0.174	0.258
cellular_component	rf	184	0.0	0.919	0.171	0.254
disease	ct	1456	0.0	1.0	0.042	0.135
disease	el	1456	0.0	1.0	0.167	0.224
disease	ka	1456	0.0	1.0	0.042	0.138
disease	rf	1456	0.0	1.0	0.042	0.135
genetic_interaction_unweighted	ct	1569	0.0	1.0	0.417	0.327
genetic_interaction_unweighted	el	1569	0.0	0.999	0.423	0.319
genetic_interaction_unweighted	ka	1569	0.0	1.0	0.839	0.361
genetic_interaction_unweighted	rf	1569	0.0	1.0	0.416	0.326
genetic_interaction_weighted	ct	1569	0.0	1.0	0.416	0.327
genetic_interaction_weighted	el	1569	0.0	0.999	0.428	0.316
genetic_interaction_weighted	ka	1569	0.0	1.0	0.836	0.367
genetic_interaction_weighted	rf	1569	0.0	0.999	0.416	0.325
molecular_function	ct	476	0.0	0.995	0.28	0.305
molecular_function	el	476	0.0	0.998	0.404	0.285
molecular_function	ka	476	0.0	1.0	0.277	0.307
molecular_function	rf	476	0.0	0.995	0.28	0.305
pathway	ct	555	0.001	1.0	0.274	0.342
pathway	el	555	0.001	1.0	0.236	0.338
pathway	ka	555	0.001	1.0	0.463	0.49
pathway	rf	555	0.001	1.0	0.228	0.334
phenotype	ct	1358	0.0	0.998	0.072	0.163
phenotype	el	1358	0.0	0.998	0.253	0.195
phenotype	ka	1358	0.0	1.0	0.07	0.169
phenotype	rf	1358	0.0	0.998	0.072	0.164
protein_interaction_unweighted	ct	1657	0.0	1.0	0.07	0.163
protein_interaction_unweighted	el	1657	0.0	0.933	0.065	0.157
protein_interaction_unweighted	ka	1657	0.0	1.0	0.304	0.455
protein_interaction_unweighted	rf	1657	0.0	0.926	0.066	0.154
protein_interaction_weighted	ct	1657	0.0	1.0	0.071	0.164
protein_interaction_weighted	el	1657	0.0	0.945	0.438	0.261
protein_interaction_weighted	ka	1657	0.0	1.0	0.302	0.456
protein_interaction_weighted	rf	1657	0.0	0.931	0.069	0.159

Table 2. Backup position values for every kernel after integration

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels